Stemcell, 100-1452, Anti-Human IL-4 Antibody, Clone MP4-25D2

This rat monoclonal antibody (clone MP4-25D2) reacts with human interleukin 4 (IL-4). IL-4 is an ~15 kDa protein primarily composed of a four-helix bundle (Powers et al.) and is produced by a host of immune cells including T helper 2 (Th2) cells, basophils, eosinophils, and mast cells (Gadani et al.). It exhibits high affinity for the IL-4 receptor alpha (IL-4Rα) chain, which dimerizes with either the common gamma chain (γc) or IL-13 receptor alpha 1 (IL-13Rα1), leading to activation of downstream JAK-STAT signaling (Heller at al.). IL-4 is involved in the differentiation of CD4+ T lymphocytes into Th2 cells (Silva-Filho et al.), class switching of B cells to IgE (Geha et al.), and activation of M2 macrophages with IL-13 via an alternative pathway (Gordon et al.).