Stemcell, 100-1455, Anti-Human Perforin Antibody, Clone deltaG9

This mouse monoclonal antibody (clone deltaG9) reacts with human perforin. Perforin is an ~70 kDa protein consisting of four domains: the N- and C-termini, which are related to its function, and two central domains that share similarities to complement proteins C6 - C9. Perforin is involved in the perforin/granzyme apoptosis pathway and is produced by natural killer and cytotoxic T cells. Upon contact with a target cell, perforin monomers are released and aggregate to form pores in the membrane of the target cell, disrupting its membrane integrity. This allows granzyme B to enter the target cell and initiate apoptosis of virally infected and transformed cells.