Stemcell, 100-1591, Anti-Human CD3 Antibody, Clone SK7

This monoclonal antibody reacts with the ~20 kDa cluster of differentiation 3 epsilon (CD3ε) subunit of human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ~95% of mature T cells and natural killer T cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. The CD3 complex consists of subunits γ, δ, ε, η, and ζ and binds noncovalently with the TCR. It is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating expression of the TCR on cell surfaces. Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related to type 1 transmembrane proteins and members of the immunoglobulin superfamily. Mutations in the CD3 subunits have been associated with various immunodeficiency disorders including severe combined immunodeficiency (SCID).