Stemcell, 100-1618, Anti-Mouse CD69 Antibody, Clone H1.2F3

This monoclonal antibody (clone H1.2F3) reacts with mouse cluster of differentiation 69 (CD69), a type II transmembrane glycoprotein. CD69 is a 60 kDa disulfide bonded homodimer expressed on activated T cells, B cells, NK cells, neutrophils, and monocytes, where induction of CD69 rapidly occurs upon activation. CD69 is constitutively expressed on platelets and a subset of thymocytes. It functions as a co-stimulatory molecule that plays a role in activating and promoting the proliferation of T cells. Additionally, it can serve as an indicator for thymocytes engaged in T cell receptor (TCR)-mediated positive selection. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. It has also been documented that co-stimulation with the H1.2F3 antibody clone enhances the activation of T cells and macrophages. CD69 dysfunction is associated with diseases such as coccidioidomycosis and asthma. Use this recombinant monoclonal antibody in applications requiring detection of CD69, such as flow cytometry (FC).