Stemcell, 100-1620, Anti-Mouse IL-4 Antibody, Clone 11B11

This monoclonal antibody reacts with mouse interleukin-4 (IL-4), a 14 kDa cytokine that is expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. IL-4 is a lymphoid cell growth factor and signals through the IL-4 receptor alpha chain (IL-4Rα) upon binding. This causes the stimulation of activated B and T lymphocytes as well as the differentiation of B cells into plasma cells. Use this recombinant monoclonal antibody in applications requiring detection of IL-4, such as flow cytometry (FC), and the unconjugated antibody in immunocytochemistry (ICC), immunohistochemistry - frozen sections (IHC-F), and FC.

IL-4 has the capability to attach and transmit signals through three different cell surface receptors: CD124, CD124 in combination with the common gamma chain (type I complex), or CD124 combined with CD213a1 (type II complex). Signal transducer and activator of transcription 6 (STAT6) has been shown to play an important role in mediating the immune regulatory signal of IL-4. IL-4 has been shown to play a role in normal wound healing and the development of allergic inflammation and asthma.