Stemcell, 100-1629, Anti-Mouse CD127 Antibody, Clone A7R34

This monoclonal antibody (clone A7R34) reacts with mouse cluster of differentiation 127 (CD127), a 60 - 90 kD type I transmembrane glycoprotein involved in the regulation of lymphopoiesis. CD127 is expressed on thymocytes, B cell precursors, T cells, and myeloid cells at the cell surface as a heterodimer with the common gamma chain (also known as CD132). This complex acts as a receptor for interleukin-7 (IL-7), which is an important cytokine in T and B cell development as well as in mature T cell homeostasis. Use this recombinant monoclonal antibody in applications requiring detection of CD127, such as flow cytometry (FC).

Thymic stromal lymphopoietin (TSLP), a second cytokine, also binds to the receptor complex of CD127 and is involved in trigger activation of dendritic cells, allergy, and autoimmunity. CD127 has been reported to be a useful marker for identifying memory and effector T cells. The A7R34 antibody clone has been shown to block IL-7Rα signaling when administered in vivo.