Stemcell, 100-1632, Anti-Mouse KLRG1 Antibody, Clone 2F1

This monoclonal antibody (clone 2F1) reacts with the mouse killer cell lectin-like receptor G1 (KLRG1), a 30 - 38 kDa homodimer receptor and a member of the lectin-like type 2 transmembrane receptor family of proteins. This receptor is expressed by activated, mature natural killer (NK) cells and by effector and memory T cells. KLRG1 expression has been associated with reduced proliferative capacity of activated T lymphocytes or reduced effector functions of activated NK cells. It has also been noted that cell surface expression of KLRG1 is upregulated by expression of the major histocompatibility (MHC) class I molecules, and this can be mediated by interactions with class I-specific Ly49 inhibitory receptors. The expression of mouse KLRG1, using 2F1 antibody clone, has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. Use this recombinant monoclonal antibody in applications requiring detection of KLRG1, such as flow cytometry (FC).