Stemcell, 100-2060, Human Recombinant IGF-I LR3, ACF

IGF-I long arginine 3 (LR3) binds to insulin-like growth factor 1 (IGF-I) receptor and is a potent activator of the PI3K/AKT pathway and ERK1/2 signaling. IGF-I is a polypeptide that belongs to the family of insulin-like growth factors similar in molecular structure to proinsulin and is a synthetic analog of insulin-like growth factor 1 (IGF-I; Francis et al). IGF-I LR3 has >100-fold reduced affinity for IGF-binding proteins (IGFBPs), which reduces availability of IGFs in cell culture (Voorhamme & Yandell). IGF-I is required for embryonic development, and is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for human pluripotent stem cell maintenance (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.). This product is animal component-free (ACF).