Stemcell, 60053, Anti-Oligodendrocyte Marker O4 Antibody, Clone 81

The 81 antibody clone reacts with the O4 antigen, a sulfated galactocerebroside (sulfatide). O-Antigens are primarily expressed on the extracellular leaflet of the myelin plasma membrane of differentiating and mature oligodendrocytes in the central nervous system, as well as on Schwann cells in the peripheral nervous system. O4 is formed during postnatal development and is a marker for cell bodies and processes of oligodendrocytes types I and II. O4 is expressed in pro-oligodendrocytes, however, it is not found on O-2A-progenitor cells. Abnormal expression of O4 has been associated with various disorders, including neurofibromatosis and schizophrenia.