Stemcell, 60164PE, Anti-Human HLA-DR Antibody, Clone LN3

The LN3 antibody reacts with the HLA-DR antigen, a major histocompatibility complex (MHC) class II receptor encoded within the human leukocyte antigen (HLA) complex on chromosome 6. HLA-DR is a heterodimeric transmembrane glycoprotein comprising non-covalently associated α (36 kDa) and β (27 kDa) subunits. MHC class II plays a central role in the presentation of antigen-derived peptides to CD4+ T cells, along with CD3/TCR and CD4. HLA-DR is primarily expressed on the surface of antigen-presenting cells, including B cells, dendritic cells, monocytes, macrophages, thymic epithelial cells, and activated T and natural (NK) cells. The LN3 antibody binds to an extracellular epitope that reportedly resides within the HLA-BR1 subunit of HLA-DR.