Stemcell, 72092, Dexamethasone

Dexamethasone is a synthetic glucocorticoid, similar to the natural glucocorticoid hydrocortisone. Dexamethasone has an increased affinity for glucocorticoid receptors when compared to the natural hydrocortisone ligand (Kd = 5 nM vs 17 nM).

REPROGRAMMING

· Promotes transdifferentiation of hepatocytes from mouse pancreatic cells (Shen et al.).

DIFFERENTIATION

· Promotes osteogenic, adipogenic, and chondrogenic differentiation of human mesenchymal cells (Jaiswal et al., Mackay et al., Pittenger et al.).

· Promotes osteogenic, adipogenic, and chondrogenic differentiation of mouse mesenchymal cells (Tropel et al.).

· Promotes differentiation of mature hepatocytes from mouse and human embryonic stem (ES) cells (Cai et al., Kubo et al.).

· Promotes maturation of fetal mouse hepatocytes (Kamiya et al.).