Stemcell, 72152, LY294002

Name: LY294002
Brand: Stemcell
SKU: 72152

Size: 25 mg, PI3K/AKT pathway inhibitor; Inhibits PI3K

Catalog Number: 72152

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size25 mg

TagsProduct Types Small Molecules

Description

LY294002 is a PI3K inhibitor that has greater potency and selectivity than quercetin, the structure on which it is based. LY294002 inhibits PI3K (IC₅₀ = 1.4 µM) and also shows activity against CK2, but not PI4K, EGFR, PDGFR, MAPK, PKA, or PKC. (Davies et al., Vlahos et al.)

MAINTENANCE AND SELF-RENEWAL

· Suppresses proliferation and self-renewal of mouse embryonic stem (ES) cells (Lianguzova et al., Paling et al.).

DIFFERENTIATION

· Promotes differentiation to insulin-producing cells from mouse ES cells (Hori et al.).

· Inhibits myotube formation from myoblasts (Coolican et al., Jiang et al.).

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Stemcell, 72152, LY294002

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