Stemcell, 72192, Prostaglandin E2

Prostaglandin E₂ (PGE₂) is the most biologically active and well-studied prostaglandin. It binds with very high affinity to the EP1, EP2, EP3, and EP4 receptors (Ki = 9.1, 4.9, 0.33, 0.79 nM respectively). (Abramovitz et al., Bos et al.)

MAINTENANCE AND SELF-RENEWAL

· Required for the development of hematopoietic stem cells (HSCs) in mice and zebrafish (North et al.).

· Improves engraftment of mouse HSCs, possibly through increasing homing, survival, and/or self-renewal (Hoggatt et al. 2009, Hoggatt et al. 2013, North et al.).

DIFFERENTIATION

· Promotes differentiation of hematopoietic progenitor cells from mouse, macaque, and human embryonic stem cells (Gori et al., North et al., Woods et al.).

· Promotes differentiation of myeloid-derived suppressor cells from hematopoietic progenitors (Sinha et al.).

· Promotes differentiation of Th17 cells from naïve T-cells (Boniface et al.).