Stemcell, 72342, StemRegenin 1

StemRegenin1 (SR1) is an antagonist of the aryl hydrocarbon receptor (AHR). It promotes ex vivo expansion of CD34+ human hematopoietic stem cells and the generation of CD34+ hematopoietic progenitor cells from non-human primate induced pluripotent stem cells. SR1 has been shown to collaborate with UM729 in preventing differentiation of acute myeloid leukemia (AML) cells in culture. SR1 also stimulates the proliferation and differentiation of CD34+ hematopoietic progenitor cells into dendritic cells.

MAINTENANCE AND SELF-RENEWAL

· Promotes maintenance and expansion of human hematopoietic stem cells in culture (Boitano et al., Csaszar et al.).

DIFFERENTIATION

· Stimulates differentiation of CD34+ hematopoietic progenitor cells into functional human dendritic cells (Thordardottir et al.).

· Promotes hematopoietic differentiation of induced pluripotent stem cells (iPS). (Gori et al.).

CANCER RESEARCH

· Collaborates with UM729 in preventing differentiation of AML cells in culture (Pabst et al.).