Stemcell, 72364, (+)-Bay K8644

(+)-Bay K8644, a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions (Hess et al.; Nowycky et al.; O'Neill et al.; Ravens et al.; Yamamoto et al.). (+)-Bay K8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects (Artigas et al.; Franckowiak et al.; Ravens et al.).

REPROGRAMMING

· When combined with BIX-01294, enables reprogramming of mouse embryonic fibroblasts after transduction with OCT4 and KLF4 only (Shi et al.).

DIFFERENTIATION

· Increases neuronal differentiation from neural stem and progenitor cells (NSCs) derived from the brains of postnatal mice (D'Ascenzo et al.).