Stemcell, 72372, 16,16-Dimethyl Prostaglandin E2

16,16-dimethyl Prostaglandin E2 (16,16-dimethyl PGE2) is a competitive inhibitor of 15-hydroxy PGDH (North et al.; Ohno et al). 16,16-dimethyl PGE2 acts as an agonist on most prostaglandin E (EP) receptor subtypes (Coleman et al.; Robert et al.) with a Kd for activation of about 1 nM (Coleman et al.). 16,16-dimethyl PGE2 is supplied in methyl acetate solution at 10 mg/mL (26 mM).

MAINTENANCE AND SELF-RENEWAL

· Increased hematopoietic stem and progenitor cell (HSPC) numbers in zebrafish aorta-gonad-mesonephros (AGM) region and mouse bone marrow (North et al.).

· Mediates the effects of WNT on zebrafish HSPC self-renewal (Goessling et al.).