Stemcell, 72462, Gö6983

Gö6983 inhibits several isoforms of protein kinase C (PKC; IC₅₀ = 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively) (Gschwendt et al.).

REPROGRAMMING

· Enhances reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells (Dutta et al.).

· Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, RepSox, Forskolin, SP600125, Valproic Acid, and Y-27632 (Hu et al.).

MAINTENANCE AND SELF-RENEWAL

· Inhibits differentiation and maintains pluripotency in mouse embryonic stem cells (Dutta et al.).

· Enhances human ground state pluripotent stem cell viability and growth (Gafni et al.).

· Inhibits proliferation of human primary fetal bone cells (Krattinger et al.).

· Inhibits the formation of protoplatelets from megakaryocytes derived from adult mouse bone marrow (Williams et al.).