Stemcell, 72472, GW2580

GW2580 is a selective inhibitor of cFMS kinase (IC₅₀ = 0.03 μM) (Conway et al., 2008), blocking its ability to autophosphorylate colony-stimulating factor (CSF-1 or M-CSF), which promotes the survival, proliferation, and differentiation of macrophages.

DIFFERENTIATION

· Demonstrates the importance of CSF-1 in promoting myeloid lineage bias in mouse hematopoietic stem cells (Mossadegh-Keller et al.).

· Demonstrates the importance of CSF-1 in expansion of mouse and human macrophage colonies and monocytes (He et al.; Clanchy et al.; Conway et al., 2008; Conway et al., 2005).

· Inhibits bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone (Conway et al., 2005), and in mouse models of arthritis (Conway et al., 2008).