Stemcell, 72492, HPI-1

HPI-1 is a Hedgehog (HH) pathway inhibitor that suppresses signaling through Sonic HH (IC₅₀ = 1.5 µM) without significantly affecting WNT signaling (IC₅₀ ≥ 30 µM) (Hyman et al.). HPI-1 suppresses HH activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of GLI protein or at the interaction of GLI with a co-factor (Hyman et al.).

MAINTENANCE AND SELF-RENEWAL

· Demonstrates the importance of Hedgehog pathway by inhibiting proliferation mediated by the oncogenic Smoothened (SMO) mutant, SMOM2 in cultured cerebellar granule neuron precursor cells (Hyman et al.).

CANCER RESEARCH

· Reduces growth of MDA-MB-231 breast cancer cells (Kwon et al.).