Stemcell, 72552, IWP-4

Name: IWP-4
Brand: Stemcell
SKU: 72552

Size: 10 mg, WNT pathway inhibitor; Inhibits Porcupine

Catalog Number: 72552

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size10 mg

TagsProduct Types Small Molecules

Description

Inhibitor of WNT Production-4 (IWP-4) inhibits WNT signaling by inactivating Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating WNT proteins, which is essential for WNT signaling ability and secretion (Chen et al.). IWP-4 impairs WNT pathway activity in vitro with an IC₅₀ value of 25 nM (Chen et al.).

DIFFERENTIATION

· Promotes cardiomyocyte differentiation in human pluripotent stem cells after treatment with CHIR99021 (Lian et al., 2012, 2013; Sequiera et al.).

· Promotes cardiomyocyte differentiation in human embryonic stem cells following primitive streak induction with BMP4 and Activin A (Hudson et al.).

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Stemcell, 72552, IWP-4

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