Stemcell, 72632, SB202190

SB202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively (Davies et al.; Jiang et al.). As a pyridinyl imidazole inhibitor, SB202190 directly binds p38 MAP kinases in the ATP binding pocket (Fox et al.).

MAINTENANCE AND SELF-RENEWAL

· Improves the self-renewal ability of neural stem cells from NPC1-deficient mice (Yang et al.).

· Blocks adiponectin-mediated proliferation of hematopoietic stem cells (DiMascio et al.).

· Reduces BMP3-mediated proliferation of C3H10T1/2 mesenchymal stem cells (Stewart et al.).

DIFFERENTIATION

· Induces cardiomyocyte differentiation from human embryonic stem cells (Graichen et al.).