Stemcell, 72692, 1-Oleoyl Lysophosphatidic Acid

1-Oleoyl Lysophosphatidic Acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. LPA mediates a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility (Moolenaar).

DIFFERENTIATION

· Stimulates neuronal differentiation in cultured mouse or rat neural progenitor cells (Cui and Qiao; Fukushima et al.; Spohr et al.).

· Inhibits human embryonic stem (ES) cell-derived neural stem cells (NSCs) from forming neurospheres and differentiating into neurons in vitro (Dottori et al.).

· Stimulates differentiation of human adipose tissue-derived mesenchymal stem cells to myofibroblast-like cells in vitro (Jeon et al.).