Stemcell, 72772, IQ-1

IQ-1 selectively inhibits p300-dependent β-catenin signaling by binding to the PR72/130 subunit of protein phosphatase PP2A, leading to decreased phosphorylation of the β-catenin coactivator, p300, and decreased affinity of p300 for β-catenin. IQ-1 thereby inhibits β-catenin/p300 interaction while increasing β-catenin/CBP mediated transcription (Miyabayashi et al.).

MAINTENANCE AND SELF-RENEWAL

· Used with Wnt3a to maintain pluripotency of mouse embryonic stem (ES) cells in the absence of mouse embryonic fibroblasts (MEFs), serum, or exogenous leukemia inhibitory factor (LIF; Miyabayashi et al.).

· Enhances expansion of mouse ES-derived cardiovascular progenitor cells (Schenke-Layland et al.).

CANCER RESEARCH

· Induces the conversion of cancer cells to a side population of cancer stem-like cells with high levels of drug resistance and tumorigenicity (He et al.).