Stemcell, 72902, Zebularine

Zebularine, a cytidine analog, is a DNA methylation inhibitor that acts by forming a covalent complex with DNA methyltransferases (DNMTs; Zhou et al.).

DIFFERENTIATION

· Induces cardiomyocyte differentiation from rat bone marrow mesenchymal stem cells (MSCs; Naeem et al.).

CANCER RESEARCH

· Reduces proliferation of the cancer cell lines TK6, Jurkat, KG-1, and HCT116 (Stresemann et al.).

· Inhibits cell proliferation in T24 bladder carcinoma cells (Ben-Kasus et al.).

· In combination with the histone deacetylase inhibitor SAHA, reduces cell proliferation and increases apoptosis in pancreatic cancer cell lines (Neureiter et al.).

· Inhibits cell proliferation and induces apoptosis in human acute myeloid leukemia cells in vitro (Scott et al.).

· Increases the proportion of cells with cancer stem cell properties in subpopulations of human cancer cells and liver cancer cell lines (Marquardt et al.).