Stemcell, 73232, Ku-0063794

Ku-0063794 is a cell-permeable, selective inhibitor of the serine-threonine kinase mammalian target of rapamycin (mTOR), inhibiting both the mTORC1 and mTORC2 complexes (IC₅₀ = 10 nM). It shows good specificity (> 1000-fold) against 76 other protein kinases or 7 lipid kinases, including PI3 kinases (García-Martínez et al.).

MAINTENANCE

· Extends the lifespan of Toll-like receptor (TLR)-activated dendritic cells by preserving mitochondrial oxidative phosphorylation (Amiel et al.).

CANCER RESEARCH

· Inhibits cell growth by inducing G1-cell cycle arrest in mouse embryonic fibroblasts and human non-small cell lung carcinoma cell lines (García-Martínez et al.; Fei et al.).

· Inhibits tumor growth in a xenograft model of renal cell carcinoma (Zhang et al.).

· Reduces keloid (fibroproliferative dermal lesion) volume in an ex vivo keloid organ culture model, and inhibits keloid cell spreading, proliferation, migration, and invasive properties in vitro (Syed et al.).