Stemcell, 73402, Ruxolitinib

Name: Ruxolitinib
Brand: Stemcell
SKU: 73402

Size: 1 mg, JAK/STAT pathway inhibitor; Inhibits JAK1 and JAK2

Catalog Number: 73402

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size1 mg

TagsProduct Types Small Molecules

Description

Ruxolitinib is an ATP mimic that inhibits all Janus-associated kinase (JAK) family kinases with a preference for JAK-1 and JAK-2 over JAK-3 and TYK2 with IC₅₀ values of 3.3, 2.8, 428 and 19 nM respectively (Verstovsek; Quintás-Cardama et al.).

CANCER RESEARCH

· Suppresses erythroid progenitor colony formation from peripheral blood mononuclear cells of polycythemia vera patients with the constitutively active JAK2 V617F mutation. Reduces malignant cell proliferation and decreases interleukin-6 and TNF-α signaling in a JAK2 V617F-driven mouse model of myeloproliferative disorder (Quintás-Cardama et al.).

OTHER

· Promotes hair regrowth in a mouse model of alopecia areata (Xing et al.).

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Stemcell, 73402, Ruxolitinib​

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