Stemcell, 73642, (-)-Epigallocatechin Gallate

(-)-Epigallocatechin Gallate is the most abundant polyphenol catechin antioxidant present in green tea (Frémont et al.; Johnson & Maddipati; Miller & Rice-Evans) and is known to inhibit DNA methyltransferases (DNMTs; IC₅₀ = 0.21 - 0.47 μM; Lee et al.). (-)-Epigallocatechin Gallate also inhibits the formation of oxidized low-density lipoproteins (Yoshida et al.), which have a pathological role in cardiovascular diseases and atherosclerosis (Itabe et al.). (-)-Epigallocatechin Gallate has also been shown to inhibit peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine (Fiala et al.).

DIFFERENTIATION

· Inhibits bone resorption by inducing cell death of osteoclast-like multinucleated cells but not osteoblastic cells (Nakagawa et al.)

CANCER RESEARCH

·Inhibits growth and induces apoptosis in human pancreatic cancer cells in mouse xenograft model (Shankar et al., Du et al.)

· Causes cell cycle deregulation and apoptosis in human epidermoid cancer cell line, possibly via inhibition of NF-κB (Ahmad et al.).