Stemcell, 73732, ISCK03

Name: ISCK03
Brand: Stemcell
SKU: 73732

Size: 10 mg, SCF/c-KIT pathway inhibitor; Inhibits c-KIT

Catalog Number: 73732

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size10 mg

TagsProduct Types Small Molecules

Description

ISCK03 (inhibitor of SCF/c-KIT) is a cell-permeable phenyl-imidazolosulfonamide compound that inhibits KIT activity. ISCK03 inhibits SCF-induced c-KIT phosphorylation and downstream ERK phosphorylation at a concentration of 1 - 5 µM in 501mel melanoma cells (Na et al.).

CANCER RESEARCH

· Causes significant decrease in blood vessel density on human lung adenocarcinoma (A549) cells irradiated with X-rays (6 Gy; Kamlah et al.).

· Reduces cell viability and ERK1/2 phosphorylation in acute myeloid leukemia (AML)-derived cell lines (Kon et al.).

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Stemcell, 73732, ISCK03

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