Stemcell, 73822, Sirtinol

Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent histone deacetylases (HDACs), including yeast Sir2p (IC₅₀ = 68 μM; Grozinger et al.), human SIRT1 (IC₅₀ = 131 μM; Schuetz et al.), and SIRT2 (IC₅₀ = 38 μM; Grozinger et al.). It does not inhibit human HDAC1 activity (Grozinger et al.). Sirtinol also activates the auxin signaling pathway in Arabidopsis (Dai et al.).

IMMUNOLOGY

· Suppresses inflammatory signaling in human dermal microvascular endothelial cells (Orecchia et al.).

CANCER RESEARCH

· Enhances apoptosis and cell death in leukemic cells, but not in healthy leukocytes and hematopoietic progenitors (Cea et al.).

· Induces senescence-like growth arrest in human cancer cell lines MCF-7 and H1299 (Ota et al.; Wang et al.).