Stemcell, 73852, STAT5 Inhibitor

Name: STAT5 Inhibitor
Brand: Stemcell
SKU: 73852

Size: 5 mg, JAK/STAT pathway inhibitor; Inhibits STAT5

Catalog Number: 73852

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size5 mg

TagsProduct Types Small Molecules

Description

STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that specifically suppresses STAT5 (IC₅₀ = 47 µM) via binding to its SH2 domain. It shows reduced potency towards the SH2 domains of STAT1, STAT3, or LCK (Müller et al.).

IMMUNOLOGY

· Induces partial apoptosis of mature eosinophils at high concentrations (Schwartz et al.).

· Rescues IL-17 production in a proportion of restimulated TH17 clones (Zielinski et al.)

· Reduces growth of induced regulatory T cells (iTregs) in vitro (Betts et al.).

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Stemcell, 73852, STAT5 Inhibitor

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