Stemcell, 73972, BMS 493

Name: BMS 493
Brand: Stemcell
SKU: 73972

Size: 1 mg, Retinoid pathway activator; Activates pan-retinoic acid receptor

Catalog Number: 73972

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Category

Stem Cell Markers

Pack Size1 mg

TagsProduct Portfolios Dendritic Cell Research Cell Differentiation and Maturation

Description

BMS 493 is an inverse agonist of the pan-retinoic acid receptors (RARs). RARs are ligand-dependent transcription factors that regulate gene networks that control cell growth, differentiation, survival, and death (Germain et al.). BMS 493 has been shown to increase nuclear receptor co-repressor (NCoR) interaction with RARs (Germain et al.; Rinkevich et al.).

DIFFERENTIATION

· Affects development of bronchial tubule formation in mice (Chazaud et al.).

· Inhibits activation of immature dendritic cells (Geissmann et al.).

CANCER RESEARCH

· Inhibits differentiation of leukemic blasts (Kamashev et al.).

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Stemcell, 73972, BMS 493

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