Stemcell, 73982, GANT 58

Name: GANT 58
Brand: Stemcell
SKU: 73982

Size: 10 mg, Hedgehog pathway inhibitor; Inhibits GLI1

Catalog Number: 73982

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Category

Differentiation Media

Pack Size10 mg

TagsProduct Portfolios Hematopoietic Stem and Progenitor Cell Research Expansion and Differentiation

Description

GANT 58 inhibits the Hedgehog signaling pathway downstream of Smoothened and Suppressor of Fused (SUFU) leading to GLI1 nuclear accumulation (Joo et al.; Stanton & Peng). GANT 58 demonstrates antiproliferative and antitumor activity in vivo (Beauchamp et al.; Joo et al.).

CANCER RESEARCH

· Reduces anchorage-independent growth in Ewing Sarcoma cells (Beauchamp et al.; Joo et al.).

· Inhibits prostate cancer tumor growth (Lauth et al.).

· Causes cell cycle arrest and apoptosis in acute leukemia T cells (Hou et al.).

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Stemcell, 73982, GANT 58

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