Stemcell, 74012, D4476

D4476 is a selective, potent, and cell-permeant inhibitor of casein kinase (CK) 1 (Rena et al.). It inhibits CK1 and CK1δ from S. pombe (IC50 = 200 nM and 300 nM, respectively; Bain et al.; Rena et al.). It also inhibits transforming growth factor β1 (TGF-β1) type I receptor (ALK5) with IC50 = 500 nM (Rena et al.).

REPROGRAMMING

· Along with forskolin (Catalog #72112) and 2-methyl-5-hydroxytryptamine, reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.).

· Reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.).

CANCER RESEARCH

· Induces apoptosis of multiple myeloma cell lines (Hu et al.).

· Exhibits anti-leukemic activity by selectively killing leukemia stem cells over normal hematopoietic stem and progenitor cells (Järås et al.).