Stemcell, 74022, JAK Inhibitor I

Name: JAK Inhibitor I
Brand: Stemcell
SKU: 74022

Size: 1 mg, JAK/STAT pathway inhibitor; Inhibits JAK1, JAK2, and JAK3

Catalog Number: 74022

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size1 mg

TagsProduct Types Small Molecules

Description

Janus Associated Kinase (JAK) Inhibitor I is a pyridine-containing tetracycle that disrupts JAK activity by interacting with the ATP binding domain. This inhibitor inhibits mouse JAK3 with Ki = 5 nM, JAK family members TYK2 and JAK2 with IC50 = 1 nM, and mouse JAK1 with IC50 = 15 nM, while showing weaker inhibition of other kinases (Thompson et al.).

REPROGRAMMING

· Inhibits the generation of mouse induced pluripotent stem cells (Efe et al.; Kim et al.).

IMMUNOLOGY

· Inhibits anti-viral response associated with JAK/STAT pathway activation (Xu et al.).

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Stemcell, 74022, JAK Inhibitor I

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