Stemcell, 74152, FK506

Name: FK506
Brand: Stemcell
SKU: 74152

Size: 50 mg, Calcineurin/NFAT pathway inhibitor; Binds FKBP-12

Catalog Number: 74152

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size50 mg

TagsProduct Types Small Molecules

Description

FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.). It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.).

MAINTENANCE AND SELF-RENEWAL

· Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.).

· In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.).

IMMUNOLOGY

· Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.).

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Stemcell, 74152, FK506

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