Stemcell, 74172, NU7026

NU7026 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway. NU7026 sensitizes cells to radiation and has potential for anticancer therapies (Veuger et al.). NU7026 is also reported to increase the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Riesenberg & Maricic; Zhang et al.).

GENOME EDITING

· Increases precise genome editing by promoting HDR at the expense of NHEJ in human pluripotent stem cells (Riesenberg & Maricic; Zhang et al.).

CANCER RESEARCH

· Sensitizes human cancer cell lines to DNA double-strand break-inducing therapy (chemo- or radio-therapy) by inhibiting DNA-PK activity and inducing cell cycle arrest at G2/M phase (Albarakati et al.; Ma et al.; Niazi et al.; Willmore et al.; Yang et al.).