Stemcell, 78067.1, Human Recombinant TGF-beta 1

Add this high-quality human recombinant transforming growth factor beta 1 (TGF-β1) to your cell culture workflow. Its verified endotoxin level of ≤ 0.2 EU/μg, measured using the LAL method, allows confidence for use across multiple applications. A member of the TGF-β superfamily, TGF-β1 regulates diverse cellular phenotypes. TGF-β1 binds to serine-threonine kinase type I and II receptors and activates signal transduction through SMAD2/3 proteins.

TGF-β1 has been used for:

hPSC CULTURE MAINTENANCE

● Use TGF-β1 together with basic fibroblast growth factor (bFGF) to support the culture of undifferentiated human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells (Amit et al. Biol Reprod, 2004).

EXOGENOUS CELL SIGNALING

● Regulate a variety of functions, including cell proliferation, differentiation, and metabolism (Massagué Nat Rev Mol Cell Biol, 2000; McDowell et al. Curr Biol, 1997).

IMMUNE CELL HOMEOSTASIS

● Modulate B cell responses and mediate immunosuppressive effects on T cells and neutrophils (Letterio & Roberts Annu Rev Immunol, 1998).