Thermo Fisher, 25003-154630, Hypersil GOLD™ C18 Selectivity HPLC Columns

Hypersil GOLD™ C18 Selectivity HPLC Columns is designed for reversed-phase HPLC and LC/MS analysis where strong peak shape, resolution, and broad pH capability are required. This configuration is a 150 mm × 4.6 mm analytical column packed with fully porous 3 µm ultrapure silica particles. The stationary phase uses C18 selectivity with proprietary derivatization and endcapping and carries the USP L1 classification. The packing has a 175 Å pore size, 220 m²/g surface area, and 10% carbon load. The operating pH range is 1 to 11, the maximum temperature is 60 °C, and the pressure rating is 5800 psi (400 bar). These operating limits allow the column to support a wide range of reversed-phase gradients while retaining the column geometry and particle size needed for conventional analytical HPLC. The endcapped silica surface is built for reduced peak tailing and narrow peaks, which supports efficient quantitative and qualitative analyses. The 4.6 mm internal diameter also fits common analytical HPLC flow regimes, while the 3 µm particles provide higher efficiency than traditional 5 µm formats without changing the intended C18 separation mechanism. The exact configuration is supplied as one analytical column. Its combination of a 175 Å pore structure, 3 µm fully porous particles, and 4.6 mm internal diameter supports conventional analytical flow paths while retaining the pressure capability needed for efficient 3 µm separations.