Thermo Fisher, 26133, CT(PEG)12 Carboxy-PEG-Thiol Compound

Quantity: 100 mg
Unit Size: Each
CT(PEG)12 is monodentate thiol-terminated and carboxylic acid pegylation reagent. The PEG compound has a defined molecular weight and spacer length and is useful for modifying surfaces such quantum dots, self-assembled monolayers and magnetic particles. Functionalization of solid surfaces with this polyethylene glycol reagent provides carboxylate “handles“ for protein immobilization via EDC crosslinking and significantly reduces nonspecific protein binding and provides. Highlights:
• Metal-binding– terminal monodentate thiol reacts spontaneously with gold surfaces through dative binding
• Carboxylate– terminal carboxylic acid group allows conjugation to amine-containing affinity ligands using carbodiimide (EDC) and Sulfo-NHS crosslinking chemistry
• Polyethylene glycol– PEG groups are flexible, non-immunogenic, hydrophilic, and significantly reduce nonspecific binding of surfaces for protein methods
• Spacer arm– 12-unit PEG spacer is nearly 48 angstroms long, minimizing steric hindrance for protein immobilization and binding assays Specifications:
• Alternative name: Carboxy-PEG12-Thiol
• Chemical name: 1-mercapto-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid
• Chemical formula: C27H54O14S
• Molecular weight: 634.77
• Spacer arm: 47.8 angstroms
• Form: colorless to pale yellow liquid
• Solubility: dissolve in DMSO or DMF for use