Description
Key facts
CAS number:41443-28-1,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:187.15 Da,
Molecular formula:C9H5N3O2,
PubChem:1456,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 25 mM,
Biochemical name:1h-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one,
Biological description:Selective, potent inhibitor of nitric oxide-sensitive guanylyl cyclase.,
Canonical smiles:C1=CC=C2C(=C1)N=CC3=NOC(=O)N23,
InChi:InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H,
InChiKey:LZMHWZHOZLVYDL-UHFFFAOYSA-N,
IUPAC Name:[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cytochrome P450 3A4 (CYP3A4) also known as TDP1 and Glutaminase is an important enzyme involved in drug metabolism. Its molecular weight is approximately 57 kDa. This enzyme is highly expressed in the liver and small intestine playing an important role in the oxidative metabolism of a wide range of substrates including steroids and pharmaceuticals. CYP3A4 contains a heme group which is essential for its catalytic activity allowing it to add oxygen into organic substances.
Biological function summary
Cytochrome P450 3A4 facilitates the metabolism of endogenous compounds and xenobiotics. It is not part of a stable complex but often works in conjunction with NADPH-cytochrome P450 reductase to carry out its functions. This activity helps in maintaining the balance of hormones and processing compounds for elimination from the body. By metabolizing toxins CYP3A4 protects cells from damage and aids in the detoxification process.
Pathways
The enzyme plays a critical role in the drug metabolism and pharmacokinetics pathways. It interacts with the cytochrome P450 system which includes other enzymes like CYP1A2 and CYP2D6 contributing to the metabolic clearance of drugs. This pathway is essential in determining the half-life of medications within the system and impacts the efficacy and toxicity of therapeutic agents in humans.
CYP3A4 influences conditions such as cancer and liver disease. Impaired or altered CYP3A4 activity can lead to drug-induced liver injury or affect the treatment outcomes in chemotherapy where drug metabolism is vital. In liver disease such as hepatitis changes in CYP3A4 expression or function can affect drug response. It connects with proteins such as tumor suppressor protein p53 which is often modulated by enzymatic changes in cancer progression.
