Description
Key facts
CAS number:99614-02-5,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:293.4 Da,
Molecular formula:C18H19N3O,
PubChem:4595,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mMSoluble in ethanol to 10 mM,
Biochemical name:Ondansetron,
Biological description:Highly potent and selective 5-HT3 antagonist. Potent antiemetic *in vivo*.,
Canonical smiles:CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C,
InChi:InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3,
InChiKey:FELGMEQIXOGIFQ-UHFFFAOYSA-N,
IUPAC Name:9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Acetylcholinesterase also known by its acronym AChE breaks down the neurotransmitter acetylcholine in synaptic clefts. It is an important enzyme in cholinergic neurons primarily located in neuromuscular junctions and various central nervous system areas. AChE weighs around 68 kDa. In addition to AChE other targets include Muscarinic Acetylcholine Receptor 1 (CHRM1) a G protein-coupled receptor prevalent in brain tissue. Cytochrome P450 3A4 (CYP3A4) is prominent in the liver and intestine known for drug metabolism. GABA A receptors have various subunits like GABRB2 GABRB3 GABRG2 and GABRA4 appearing in the brain and playing roles in inhibitory neurotransmission.
Biological function summary
Proteins like AChE maintain neurotransmitter balance by degrading acetylcholine ensuring proper nerve signal termination. The GABA A receptors including subunits like GABRB2 GABRA3 and GABRG2 are integral to chloride channel function promoting inhibitory signaling within neuron complexes. CYP3A4 is part of the cytochrome P450 family and contributes to xenobiotic metabolism affecting drug processing. These proteins can be part of larger complexes that facilitate neurotransmission influencing synaptic plasticity and signal transduction.
Pathways
Several of these targets take part in critical signaling cascades. AChE functions in the acetylcholine pathways directly impacting neuromuscular and central nervous system nodes. Similarly the GABA A receptor subunit family including GABRA4 and GABRB1 figures prominently in GABAergic signaling pathways that regulate neuronal excitability. CYP3A4 is pivotal in the drug metabolism and xenobiotic pathways interacting with proteins like Mu Opioid Receptor (MOR) which are relevant for drug efficacy and detoxification processes.
Disruptions in AChE activity relate to neurodegenerative ailments such as Alzheimer's disease which involves altered neurotransmitter dynamics. CHRM1 abnormalities can also correlate with cognitive disorders and neuropsychiatric conditions. The GABA A receptor subunits including GABRA5 and GABRD often link to epilepsy and anxiety disorders due to their role in inhibitory neurotransmission. CYP3A4 impairment influences drug metabolism and can result in adverse drug reactions affecting pharmacotherapy outcomes across various conditions.
