Description
Key facts
CAS number:152121-47-6,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:377.4 Da,
Molecular formula:C21H16FN3OS,
PubChem:176155,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mM,
Biochemical name:4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole,
Canonical smiles:CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F,
InChi:InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25),
InChiKey:CDMGBJANTYXAIV-UHFFFAOYSA-N,
IUPAC Name:4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MAPK family including p38 JNK1 ERK1 ERK2 and others like MAPK12 (p38 gamma) MAPK11 (p38 beta) and ERK8 function as serine/threonine kinases. These proteins are essential in cellular signaling. The average molecular mass of these kinases ranges from 40 to 60 kDa. They are expressed in various tissues such as liver lung and brain highlighting their diverse roles in different cell types and conditions.
Biological function summary
Kinases like p38 and its related MAPK members are involved in cellular responses to stress and cytokines playing critical roles in inflammation and apoptosis. These proteins participate in large signaling complexes formed with scaffolding and regulatory proteins amplifying the transmission of environmental signals into the cell. The well-studied p38 pathway influences cellular differentiation especially in response to external stimuli.
Pathways
P38 kinases and other MAPK members integrate into the MAPK/ERK and JNK signaling frameworks. These pathways influence cellular processes such as growth and apoptosis. For instance p38 and JNK1 interact with transcription factors like AP-1 and proteins such as MEK1/2 within these pathways regulating gene expression in response to signals for maintaining cellular homeostasis.
P38 kinases and related MAPK proteins play roles in conditions like rheumatoid arthritis and neurodegenerative diseases. Their involvement in inflammatory pathways associates them with the pathological mechanisms of these diseases. Particularly MAPK12 (p38 gamma) and JNK3 are investigated for their roles in neuronal death and inflammation linking these kinases to potential therapeutic targets for diseases characterized by excessive inflammation or cell damage.
