Description
Key facts
CAS number:142880-36-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:388.5 Da,
Molecular formula:C20H28N4O4,
PubChem:132519,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:Ilomastat,
Biological description:Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.,
Canonical smiles:CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC,
Isomeric smiles:CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC,
InChi:InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1,
InChiKey:NITYDPDXAAFEIT-DYVFJYSZSA-N,
IUPAC Name:(2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
Product details:
Check out our range of MMP (Matrix Metalloproteinases) inhibitors
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MMPs play roles in conditions such as cancer metastasis and chronic inflammatory diseases like rheumatoid arthritis. During cancer progression MMPs such as MMP2 and MMP9 facilitate tumor invasion and the spread of cancer cells by breaking down basement membranes and stromal tissues. In arthritis MMPs lead to cartilage degradation causing joint damage. MMP inhibitors such as GM6001 have been explored to target these diseases by moderating excessive MMP activity presenting therapeutic potential for conditions exacerbated by uncontrolled proteolysis.
Pathways
MMPs operate within significant biological processes like the inflammatory response and cellular signaling pathways including the MAPK and NF-kB pathways. They interact with other proteins such as integrins and cytokines to modulate cellular and inflammatory responses. Such interactions impact the balance between matrix formation and degradation exemplifying their involvement in tissue homeostasis and response to injury or disease.
Biological function summary
MMPs facilitate the breakdown of extracellular matrix components impacting processes such as angiogenesis wound healing and embryonic development. They often work in concert with other proteins in the extracellular space potentially forming complexes with tissue inhibitors of metalloproteinases (TIMPs) which regulate their activity. MMPs not only maintain normal physiological function but also reactivate and remodel tissue structure during pathological conditions providing grounds for cellular migration and proliferation.
MMPs (Matrix Metalloproteinases) such as MMP1 MMP2 MMP3 MMP7 MMP8 MMP9 MMP12 MMP13 MMP14 MMP16 MT2-MMP MT4-MMP and MMP26 are enzymes that play roles in tissue remodeling and are known for degrading extracellular matrix proteins. They are often referred to as collagenases or gelatinases depending on their substrate specificity. MMPs originate from diverse tissues including the skin lung and connective tissues and they have wide-ranging molecular masses typically between 20 to 100 kDa. They can be expressed in response to cytokines growth factors and physical stress indicating their versatile roles across different tissue environments.
