Description
Key facts
CAS number:54239-37-1,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:219.28 Da,
Molecular formula:C12H17N3O,
PubChem:2755,
Nature:Synthetic,
Solubility:Soluble in ethanol to 50 mMSoluble in DMSO to 100 mM,
Biochemical name:Cimaterol,
Biological description:β adrenoceptor agonist (Ki = 2.32 μM). Active in vivo.,
Canonical smiles:CC(C)NCC(C1=CC(=C(C=C1)N)C#N)O,
InChi:InChI=1S/C12H17N3O/c1-8(2)15-7-12(16)9-3-4-11(14)10(5-9)6-13/h3-5,8,12,15-16H,7,14H2,1-2H3,
InChiKey:BUXRLJCGHZZYNE-UHFFFAOYSA-N,
IUPAC Name:2-amino-5-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzonitrile
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TSH receptor also known as TSH-R and the beta 1 beta 2 and beta 3 adrenergic receptors are key components of the G protein-coupled receptor family. The TSH receptor primarily interacts with thyroid-stimulating hormone to regulate thyroid function and it's expressed mainly in the thyroid gland. The adrenergic receptors including beta 1 beta 2 and beta 3 subtypes respond to catecholamines like adrenaline and noradrenaline and are widely distributed across tissues such as the heart lungs and adipose tissue. The known molecular mass of these proteins ranges around 80-100 kDa for the TSH receptor and 46-65 kDa for the beta adrenergic receptors.
Biological function summary
These receptors serve different but overlapping functions within the body's systems. TSH-R is essential for stimulating the thyroid hormone production impacting metabolism and energy use. The adrenergic receptors including those acting as beta agonists mediate cardiovascular pulmonary and metabolic responses to stress stimuli. While not directly forming a complex these receptors synergistically control cardiovascular dynamics and energy homeostasis. They interact with other proteins such as G proteins to commence their signaling cascade.
Pathways
These receptors are significant in several critical signaling episodes. TSH-R is a pivotal element in the thyroid-stimulating hormone signaling pathway influencing thyroid hormone production and release. Beta adrenergic receptors are involved in the adrenergic signaling pathway in cardiomyocytes affecting heart rate and force of contraction. They connect with proteins like Gs alpha subunits and adenylate cyclase which modulate cAMP levels thereby altering diverse cellular functions.
The TSH receptor plays a role in thyroid dysfunctions such as Graves' disease an autoimmune disorder where overactivity can lead to hyperthyroidism. Beta adrenergic receptors relate to conditions like heart failure where their dysregulation affects cardiac output. Disorders in adrenergic signaling involve altered expression or function of other related proteins such as phospholamban in heart failure highlighting the complexity and significance of these receptors in disease states.
