Description
Key facts
CAS number:154554-41-3,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:283.25 Da,
Molecular formula:C16H10FNO3,
PubChem:375860,
Nature:Synthetic,
Solubility:Soluble in DMSO to 5 mM (with warming)Soluble in ethanol to 5 mM (with warming),
Biochemical name:6-(2-Fluorophenyl)[1,3]dioxolo[4,5-G]quinolin-8(5h)-One,
Biological description:Potent antitumor agent. Antiproliferative, anti-angiogenic and anti-apoptotic in a dose dependent manner. Reduces cell viability (IC50 = 0.13 - 8.2 μM) and tumor invasion. Active in vitro and in vivo. Increases expression of DR5, TRIAL, p53. Reduces tumor polymerisation and caspase activation.,
Canonical smiles:C1OC2=C(O1)C=C3C(=C2)C(=O)C=C(N3)C4=CC=CC=C4F,
InChi:InChI=1S/C16H10FNO3/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12/h1-7H,8H2,(H,18,19),
InChiKey:ZMYDAPJHGNEFGQ-UHFFFAOYSA-N,
IUPAC Name:6-(2-fluorophenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Atad5 also known as ELG1 or PCNA unloader is a protein involved in DNA replication and repair. Atad5 has a molecular mass of approximately 215 kDa. You can find Atad5 mainly in the nucleus where DNA replication and repair processes occur. It is expressed in different tissues showing its widespread importance in cellular functions. The protein consists of several domains important for binding other proteins important for its function in maintaining genome stability.
Biological function summary
Atad5 plays an important role in the regulation of replication fork stability and the unloading of PCNA (Proliferating Cell Nuclear Antigen) from DNA. It works as a part of a larger complex involved in DNA replication stress response. Atad5 coordinates protein biosynthesis pathways and ensures the proper completion of the DNA replication process. Oligomyosin domains in Atad5 assist in interacting with other proteins allowing it to perform its functions effectively within the cell's nuclear machinery.
Pathways
Atad5 operates in the DNA damage response and repair processes. It orchestrates the unloading of PCNA from chromatin which is important for DNA synthesis replication fork restart and repair. Atad5 associates with other proteins like RAD17 during these processes ensuring accurate DNA replication and maintaining genomic integrity. Atad5 also affects the ATR-Chk1 signaling pathway reflecting its significant role in cellular stress responses.
Atad5 is linked to chromosomal instability and cancer. Mutations or dysfunctions in Atad5 can lead to uncontrolled or faulty DNA replication contributing to tumorigenesis. Atad5 interacts with proteins such as CHK1 in response to DNA damage and its mutation can disrupt this interaction possibly leading to cancerous growth. Additionally altered Atad5 function is associated with DNA repair disorders leading to heightened sensitivity to DNA-damaging agents and increased risk of disease.
