Description
Key facts
CAS number:228559-41-9,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:469.4 Da,
Molecular formula:C24H18F3N3O4,
PubChem:11317348,
Nature:Synthetic,
Solubility:≥23.45mg/mL in DMSO,
Biochemical name:1-(2,4-Difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl)urea,
Biological description:Highly potent, selective VEGFR-2 tyrosine kinase inhibitor (IC50 = 0.9 nM). Shows some inhibition to c-Kit, PDGFRα and FGFR-2 signaling (IC50 = 40-170 nM). Shows antiangiogenic and antitumor effects in vivo.,
Canonical smiles:COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F,
InChi:InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31),
InChiKey:LFKQSJNCVRGFCC-UHFFFAOYSA-N,
IUPAC Name:1-(2,4-difluorophenyl)-3-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]urea
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C
