Description
Key facts
CAS number:606143-52-6,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:457.7 Da,
Molecular formula:C17H15BrClFN4O3,
PubChem:10127622,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 4 mM,
Biochemical name:Selumetinib,
Biological description:Potent, selective, non-ATP competitive MEK1/2 inhibitor (IC50 MEK1 = 14 nM). Also inhibits ERK1/2 phosphorylation.,
Canonical smiles:CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO,
InChi:InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26),
InChiKey:CYOHGALHFOKKQC-UHFFFAOYSA-N,
IUPAC Name:6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Estrogen Receptor (ER) MEK1 EGFR MEK2 Androgen Receptor (AR) CSNK2A2 ROR gamma BMP2K and AAK1 are various proteins playing significant mechanical roles in cellular processes. The Estrogen Receptor also known as ERα or ESR1 has a mass of approximately 66 kDa and is abundantly expressed in breast tissue liver and ovaries. MEK1 and MEK2 both MAP2K proteins interact with the ERK/MAPK signaling pathway and are found in various tissues. EGFR another notable target is usually expressed on epithelial cells and has a mass around 170 kDa. The Androgen Receptor with a mass of 110 kDa appears in high levels in male reproductive tissues. CSNK2A2 (also called CK2 alpha' subunit) ROR gamma BMP2K and AAK1 have distinct cellular locations but contribute to signaling and regulation within cells.
Biological function summary
These targets perform critical roles in maintaining homeostasis and facilitating signal transduction within cells. Estrogen Receptor mediates estrogen signaling influencing transcription and cell proliferation. MEK1 and MEK2 act as kinases in the MAPK/ERK pathway essential for cell division and differentiation. EGFR is an important player in cell survival and proliferation and is part of a receptor tyrosine kinase complex. The Androgen Receptor regulates the expression of genes linked to male traits and reproduction occasionally forming complexes with co-regulators. CSNK2A2 aids in phosphorylation processes while ROR gamma BMP2K and AAK1 contribute to immune response and intracellular transport regulation.
Pathways
These proteins integrate into various important signaling networks. The Estrogen Receptor and Androgen Receptor are important in steroid hormone signaling pathways affecting gene expression and cellular activities. MEK1/2 linked with the MAPK/ERK pathway involves in response mechanisms to growth factors and hormones engaging with proteins like RAF and ERK. EGFR initiates numerous downstream signaling cascades including PI3K/AKT and JAK/STAT pathways influencing oncogenesis and survival. CSNK2A2 ROR gamma BMP2K and AAK1 align within pathways related to cell cycle regulation and immune signaling.
These targets are implicated in conditions such as cancer and metabolic diseases. Estrogen Receptor is notably connected to breast cancer interacting with proteins like HER2 which can alter treatment responses. Dysregulation of EGFR associates with several cancers including lung and colorectal cancer influenced by interplay with KRAS and BRAF proteins. Abnormal activity of MEK1/2 also relates to malignant cell transformation bearing connections to ERK. The Androgen Receptor has links to prostate cancer with interactions affecting diagnosis and therapy. Proteins CSNK2A2 ROR gamma BMP2K and AAK1 further involve in diverse disorders emphasizing their roles in cellular pathology.
