Description
Key facts
CAS number:446859-33-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:287.32 Da,
Molecular formula:C17H13N5,
PubChem:449054,
Nature:Synthetic,
Biochemical name:RepSox,
Biological description:Selective TGF-β type 1 receptor and ALK5 autophosphorylation inhibitor (IC50 = 4 nM for ALK5). Selective for ALK5 over a range of other kinases, including p38 MAPK, JNK1 and GSK3. Replaces Sox2 for reprogramming iPSCs. Active in vitro and in vivo. Cell-permeable.,
Canonical smiles:CC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4,
InChi:InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22),
InChiKey:LBPKYPYHDKKRFS-UHFFFAOYSA-N,
IUPAC Name:2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
