Description
Key facts
CAS number:7481-89-2,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:211.22 Da,
Molecular formula:C9H13N3O3,
PubChem:24066,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:Zalcitabine,
Biological description:Nucleoside reverse transcriptase inhibitor (NRTI). Pyrimidine nucleoside analog, substrate for reverse transcriptase. Able to induce oxidative stress. Effective against HIV replication in vivo.,
Canonical smiles:C1CC(OC1CO)N2C=CC(=NC2=O)N,
Isomeric smiles:C1C[C@@H](O[C@@H]1CO)N2C=CC(=NC2=O)N,
InChi:InChI=1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1,
InChiKey:WREGKURFCTUGRC-POYBYMJQSA-N,
IUPAC Name:4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Albumin is a protein found abundantly in the blood plasma often referred to as human serum albumin (HSA) and with a molecular mass of about 66.5 kDa. This protein plays an important mechanical role in maintaining osmotic pressure and is vital for the transport of diverse molecules such as hormones fatty acids and drugs. Albumin is synthesized in the liver and its expression is largely found in the blood accounting for over half of human serum proteins.
Biological function summary
Albumin serves diverse roles beyond transport; it also acts as a depot and carrier for many endogenous and exogenous compounds. In addition to its primary location in blood plasma albumin contributes to the buffering of pH. It does not form part of a larger complex but interacts dynamically with various other plasma proteins and small molecules due to its binding sites. It plays a part although not structurally connected in processes requiring metabolic interchange and balance.
Pathways
Albumin integrates into the lipid metabolism and homeostasis pathways. It fortifies the transport system alongside proteins such as apolipoproteins facilitating lipid and solute movement through the bloodstream. Additionally albumin indirectly influences the renin-angiotensin-aldosterone system important for blood pressure regulation intersecting with proteins such as angiotensinogen through its role in fluid distribution and vascular stability.
Albumin levels in the blood serve as a significant indicator for liver and kidney diseases such as cirrhosis and nephrotic syndrome. Albumin depletion links closely to these disorders often due to increased loss or decreased production. For instance low albumin levels associate with nephrotic syndrome where faulty kidneys result in substantial proteinuria. The involvement of receptors like CXCR4 has implications in broader renal pathophysiology which can also impact albumin turnover.
