Description
Key facts
CAS number:568-73-0,
Purity:>95%,
Form:SolidSee storage information,
Source:Salvia miltiorrhiza Bunge,
Molecular weight:276.3 Da,
Molecular formula:C18H12O3,
PubChem:114917,
Nature:Native,
Solubility:Soluble in DMSO,
Biochemical name:Tanshinone I,
Biological description:Cytotoxic to cancer cells, inhibits cell migration and invasion. Shows anti-inflammatory, Anticancer, immunosuppressive and anticoagulant agent. Active in vivo and in vitro.,
Canonical smiles:CC1=C2C=CC3=C(C2=CC=C1)C(=O)C(=O)C4=C3OC=C4C,
InChi:InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3,
InChiKey:AIGAZQPHXLWMOJ-UHFFFAOYSA-N,
IUPAC Name:1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tau also known as MAPT (microtubule-associated protein tau) is a protein with a mass of approximately 80 kDa. It primarily stabilizes microtubules in neurons and is found mainly in the brain. SHP-1 also known as PTPN6 (protein tyrosine phosphatase non-receptor type 6) has a mass of about 68 kDa and functions in hematopoietic cells such as lymphocytes and monocytes. CES2 or carboxylesterase 2 weighs around 62 kDa and is expressed predominantly in the liver and digestive tract where it plays a role in drug metabolism.
Biological function summary
Tau maintains microtubule stability which is essential for neuronal transport and function. Tau does not often form complexes but can be hyperphosphorylated affecting its function. SHP-1 is a cytoplasmic tyrosine phosphatase that regulates signaling pathways in immune cells often being part of larger signaling complexes. CES2 is involved in hydrolyzing ester and amide bonds critical for the detoxification of various substances and metabolism of some prodrugs.
Pathways
Tau closely links to the MAPK signaling pathway influencing neuronal growth and differentiation. It interacts with proteins like tubulin in microtubules. SHP-1 is an important regulator in the JAK/STAT signaling pathway modulating cytokine signaling in immune responses. It interacts with upstream kinases and downstream proteins like STAT. CES2 is integral to the xenobiotic metabolism mechanism playing a part in drug detoxification involving the cytochrome P450 enzymes.
Tau is significant in neurodegenerative diseases such as Alzheimer's Disease where tau tangles disrupt neuronal function. This connection occurs alongside amyloid-beta proteins. SHP-1 relates to autoimmune diseases affecting the regulation of immune responses due to its role in lymphocyte signaling. CES2 is relevant to drug resistance in cancer as it activates prodrugs used in chemotherapy. In such cases CES2 connects with transport proteins that regulate drug efflux or uptake.
